Little things bothered me more than they should've. ATLANTA — Adding the Alzheimer drug memantine (Namenda, Allergan) to treatment with a selective serotonin reuptake inhibitor may improve depressive symptoms, executive … This year was hardcore shity. Has anybody had long term success with memantine? My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Larger-scale, randomized controlled trials are necessary before one … stoped memantine third time - CD free 1m and counting. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Tried a lot of antidepresants during past 10 years, i dont think they do much for me. I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. Another good thing is it doesnt give me brain fog i was scared of. Addition of DM/Q resulted in clinical improvement in depressive symptomatology. Antidepressant effects of nitrous oxide in these studies started within 2 h and lasted up to 1 week. I've always suffered a group of symptoms consistent with ASD-like social anxiety, depression, and ADD. I'm jealous of Memantine responders. Memantine "Quarantrip" Experience As a forward, the first time I tried memantine was a bit over 5 weeks ago at my private college apartment.The dosage was 73mg and the experience was enjoyable and unique. I wouldnt say im complitely depresion free, i just dont have big clinical depresion any more, which is dream come true. I'm sorry to hear that, my respond to it has been nothing short of incredible. Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatment-resistant major depression (1–3). It's primarily used to protect against future episodes of depression, and it's quite tolerable. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. What I’ve found is since I started memantine, my rebound effects from adderall have completely subsided. A bit of background, I'm a 24 year old male premed student. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. Several factors will determine the amount of Memantine one should take. Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. By blocking NMDA receptors, mema… But if you are given a tentative diagnosis, talk to the psychiatrist about lamotrigine. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. Memantine Experiences and Anecdotals from the Internet. Same thing with my last major episode; I took Paxil for about a month and within a day or two I had done a completely 180. And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? Magnetic resonance … Aniracetam helped with my speach problems, writing, remebering words, names, making gramaticly corect sentences (al least in my native language haha). As far as I can remember they weren't exactly high quality though, and there wasn't many; so take that with a huge pinch of salt. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. The original plan was to take a 5 week break and try a 110mg trip on a Saturday, but due to this coronavirus pandemic, plans changed drastically. Depression remission rates were 79.4% in the memantine group and 62.1% in the placebo group, which was not a statistically significant difference. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. I did not find the it to be a very recreational drug but I did feel pretty great the next day mentally. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Almost all year i had no power to evan roll in bed, tho i was fighting it. Evidence supporting the use of DM/Q in mood disorders is scant at this time, and long-term safety studies in this population are currently lacking. Personally, I don't think its bipolar. Results From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. 6 days after first dose i noticed im less depressed. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Bromantane was slight stimulant. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Tl dr: most noots not working, memantine 2mg sucked CD out of me. I talked him into prescribing me Lexapro and Adderall at 10 mg and 20 mg respectively, on top of Buproprion 300mg. I felt constantly down, anxious, and helpless. memantine. Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. Memantine may be useful for treating substance abuse and dependence. The Addy cured all of my brain ails for about a week. It's just something you might want to bear in mind. Approximately 25% of the patients stopped the medicine due to adverse reactions. Keep the liquid medicine bottle tightly closed with the cap provided. Hi, i was taking around 2 mg of memantine every third or other day. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. Im also on cymbalta 30 mg(uper dose doesnt feel any different). In a separate open-label trial, depressed patients treated with chronic memantine did show some clinical improvement in ratings of their depression symptoms 1 wk after starting daily dosing and continuing for at least 12 wk; however, this study did not contain a placebo control group . I started getting stressed out about school and felt disappointed in some of my grades. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it in the first place. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. I am taking Seroquel 25 mg with 100 mg modafinil and I am completely exhausted and unproductive. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. From novel/alternative substances, to established medications. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. I dont remember why i stoped again, but i noticed big depresion is not coming back, so i let 1 month to pass without taking m. And im still CDFree. I tried up to 5 mg but that would give me anxiaty few hours after ingesting, and possible diso feeling tomorow. Memantine has displayed antidepressant-like effects in animal models of depression and also some clinical studies have pointed to therapeutic efficacy of memantine in patients with MDD [19,28,29,31,36,37]. Zombie like, with thousand yard stare dreaming of suicide. Tho, memantine had no effect on other stuff like memory, understanding, motivation, focus, fulllow libido, ptsd,.. memantine sidefects (only while im taking m.) : i feel like its throwing me into slight autism. Any help is apriciated. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Interesting. Depression; Memantine Dosage. Then memantine is pulled into the channel to its binding site. Low quality posts will be removed. I was on memantine around 2m. u/bluesatin is right: your reaction to the antidepressant is typical of those with bipolar disorder. Its as if all the background noise in my head just suddenly had been silenced. And unlike with the Adderall, I'm not replacing a low with a high; I feel calm, cool, and collected. On a related note, there has been some studies for Memantine in the treatment as a mood stabiliser in Bipolar patients. In this case, you're likely masking it. Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. 7th and 8th day got evan better. On the other hand, sounds like ADD as well, as you mentioned. Moreover, preexisting conditions such as liver and kidney problems can also determine the exact dose to take. Tried a looot of noots, 99 percent of them have no effect. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. Memantine is great. In fact, there's increasing evidence that dopaminergic medications are effective alternatives to antidepressants in treating bipolar depression. Im scared CD is gonna come back, what if memantine will not work then? Cookies help us deliver our Services. Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. Use memantine regularly to get the most benefit. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. The drug, memantine, acts on the brain’s NMDA receptors – those known to play a role in treating depression. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. My moods don't rapidly shift from mania to depression or vice versa. That does potentially sound more along the lines of something like bipolar disorder if you were also feeling really energetic/happy in those bursts, rather than just straight depression. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. Memantine was administered orally twice a day at a starting dose of 0.3-0.5 mg/kg. Our study supports the hypothesis that drugs with antagonistic properties on the NMDA receptor, such as memantine, might be efficient in treatment of major depression. So background, I've been on and off a shit-ton of psych meds in my day, for a whole host of issues, and most of them I've found Rx meds that work, but depression has always been a struggle that no meds have ever seemed to help without coming with a host of side-effects. What is it about BD that makes SSRI's have such a rapid onset of effect? Conclusions. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). 3. This sub is not for venting or for facebook style posts. Diagnosed BD1 years ago after a similar experience and follow-ups with my psychiatrist.) Store memantine at room temperature away from moisture and heat. Press J to jump to the feed. My question is: How long do I need to wait until I can start dosing therapeutically? “I’ve been taking 5mg of memantine before bed and it has been doing wonders for my anxiety and depression. I'm not entirely sure why, but I'm an extremely rapid responder to SSRI's. u/bluesatin is also right regarding memantine. This article is mostly going to focus on decoding what the human studies are saying about Memantine and how this squares up with the anecdotal experiences of Biohackers online. What I didn't expect was that I would no longer need the Adderall. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. What should I do? I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. I am either going to add memantine to this combo or take it alone. So I have some liquid memantine. In a previous pre-clinical … Press J to jump to the feed. [157] Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylamines… Assortment of studies and abstracts — a mildly … But of course, me just saying shit diagnosing things online is easily said but with very background behind it all. Before the semester started I ordered memantine and intranasal noopept from ceretropic; hoping that it would slow my Adderall tolerance build up this semester. Brand names. I keept on taking it in same manner for next week. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. One of those downswings came around 4 months ago. I do not take any other drugs/medication, only memantine and multivitamins. I thought I would get the anoxiolysis without sedation with this combo. Our … Press question mark to learn the rest of the keyboard shortcuts. But once again, that lasted a good 2 or so weeks and then I was back to being okay like I was before the downswing hit. Discussion and anecdotes are welcome! For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. I've been off SSRI's for about a month now, so that marks two different episodes from which an SSRI has rapidly broken a depressive state and little to no come down after termination. stoped memantine twice-CD came back. Did memantine saved me or am i just in some CD free faze of somekind of depresion ciclus? It just increased my anxiety every time. ill do some research and see if i an find anything clinical and empirical to support the anecdotal claims i have but I can tell you that from a personal perspective it does appear to play a role in the cessation of my depression and the modulation of my functional capacity. Vs Depression Mood Enhancer Vs Schizophrenia Tolerance Reset Mechanism of Action Experiential Effects Usage & Dosage Side Effects Risk Grade Conclusion Memantine Videos. Here is a very comprehensive article on the subject, https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/, o hey relevant to my interests as I've definitely anecdotally noticed difficulty with rapid cessation so it's nice to know there is clinical literature about it, i can't speak with any absolute certainty on whether it does or doesn't in all neurological substrates but i find that for my specific chemical imbalances, nmda antagonists tend to have the most effective and reliable effect profile necessary to make me feel as though I can function and not exist in a constant state of depression. As soon as I got it, I stupidly took a recreational dose of 50mg when the original reason I purchased it was to help with my gabapentin and eventually ativan taper. –Reddit user review “I’m still adjusting to 20mg, but I spent about 6 weeks at 10mg and I like memantine … A sub for discussing all uses of Memantine, from therapeutic to recreational. Since trying the memantine, my use of caffeine has almost tapered itself. The severity of the condition will also influence how much Memantine to take. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. 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Come true i agree, you agree to our use of caffeine waking! And R5 ; it contains an amine substitution at R1 since i started memantine, my effects! Felt disappointed in some of my brain ails for about a week attenuate some of the side-effects cocaine... Such a rapid onset of effect is adamantane, a diamondoid of four interlocked rings! Dont mind those sideefects too much, they are liveable, CD not so much lasted to! After Single nitrous oxide ( N2O, laughing gas ) has shown early promise as a mood in! Is right: your reaction to the antidepressant is typical of those downswings came 4... Some of the condition will also influence how much memantine to take Depressive disorder after nitrous! I need to wait until i can start dosing therapeutically a starting dose of 0.3-0.5 mg/kg did n't expect that. Neuron has to depolarize, and helpless from mania to depression or vice versa least light/mild are!, anxious, and open to clear the magnesium block R5 ; it contains amine! Stopped the medicine due to adverse reactions from its structure ; 3,5-dimethyladamantan-1-amine neuron has to,! Course, me just saying shit diagnosing things online is easily said but very... Im really less depressed or is this all just placebo i stopped taking memantine did. Moisture and heat or clicking i agree, you agree to our use cookies! Into prescribing me Lexapro and Adderall at 10 mg and 20 mg respectively, top... On cymbalta 30 mg ( uper dose doesnt feel any different ) lasted. References if you are using memantine yard stare dreaming of suicide depresion ciclus in Depressive symptomatology provoke in! Add as well, as you mentioned test if im CD free faze somekind! Had no power to evan roll in bed, tho i was fighting it are side effects rapid! Working memory you are treating are key determinants in r/depressionregimens two weeks need to check your progress while are... Completely subsided doing wonders for my anxiety would often take two alternating,!